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La Fondazione, a seguito di un accordo di collaborazione con il Consorzio C.A.R.S.O., sito nel Campus, utilizza le infrastrutture e le apparecchiature scientifiche del Consorzio. Svolge attività di ricerca nel campo delle omiche per la Medicina di Precisione e per la Terapia Personalizzata nel campo delle malattie renali

L’attività di ricerca è documentata dalle seguenti pubblicazioni:


Sallustio F, Costantino V, Cox SN, Loverre A, Divella C, Rizzi M, Schena FP. Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvescicle-shuttled decorin. Kidney Int. 83: 392-403, 2013. (I.F. 7.916)

Sallustio F, Serino G, Costantino V, Curci C, Cox SN, De Palma G, Schena FP. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. PLoS One. 8: e68296, 2013. (I.F. 3.730)

Sallustio F, Cox SN, Serino G, Curci C, Pesce F, De Palma G, Papagianni A, Kirmizis D, Falchi M, Schena FP. Genome-wide scan identifies a copy number variable region at 3p21.1 that influences the TLR9 expression levels in IgA nephropathy patients. Eur J Hum Genet. 23: 940-8, 2014. (I.F. 4.225)

Serino G, Sallustio F, Curci C, Cox SN, Pesce F, De Palma G, Schena FP. Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy. Nephrol Dial Transplant. 30:1132-9, 2015. (I.F. 3.488)

Cox SN, Serino G, Sallustio F, Blasi A, Rossini M, Pesce F, Schena FP. Altered monocyte expression and expansion of non-classical monocyte subset in IgA nephropathy patients. Nephrol Dial Transplant. 2015 Mar 13. pii: gfv017. [Epub ahead of print] PubMed PMID: 25770168. (I.F. 3.488)

Pesce F; Diciolla M; Binetti G; Naso D; Ostuni VC; Di Noia T; Vagane AM; Bjorneklett R; Suzuki H; Tomino Y; Di Sciascio E; Schena FP. Clinical decision support system for end-stage kidney disease risk estimation in IgA nephropathy patients. Nephrol Dial Transplant 31: 80-6, 2015 (I.F. 3.488)

Serino G, Pesce F, Sallustio F, De Palma G, Cox SN, Curci C, Zaza G, Lai KN, Leung JC, Tang SC, Papagianni A, Stangou M, Goumenos D, Gerolymos M, Takahashi K, Yuzawa Y, Maruyama S, Imai E, Schena FP. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. Kidney Int. 2015 Nov 18. doi: 10.1038/ki.2015.333. (I.F. 8.563)

Sallustio F, Serino G, Cox SN, Dalla Gassa A, Curci C, De Palma G, Banelli B, Zaza G, Romani M, Schena FP. Aberrantly Methylated DNA Regions Lead to Low Activation of CD4+ T Cells in IgA Nephropathy. Clin Sci (Lond). 2016,130: 735-748 (I.F. 5.598)

Piccinonna S, Ragone R, Stocchero M, Del Coco L, De Pascali SA, Schena FP, Fanizzi FP. Robustness of NMR-based metabolomics to generate comparable data sets for olive oil cultivar classification. An inter-laboratory study on Apulian olive oils. Food Chem. 2016; 199:675-83. doi: 10.1016/j.foodchem.2015.12.064. PubMed PMID: 26776024. (I.F.4.052)

Inker LA, Mondal H, Greene T, Masaschi T, Locatelli F, Schena FP, Katafuchi R, Appel GB, Maes BD, Li PK, Praga M, Del Vecchio L, Andrulli S, Manno C, Gutierrez E, Mercer A, Carroll KJ, Schmid CH, Levey AS. Early Change in Urine Protein as a Surrogate End Point in Studies of IgA Nephropathy: An Individual Patient Meta-analysis. Am J Kidney Dis. 2016; 68:392-401. doi: 10.1053/j.ajkd.2016.02.042. PubMed PMID: 27032886. (I.F. 6.269)

Curci C, Sallustio F, Serino G, De Palma G, Trpevski M, Fiorentino M, Rossini M, Quaglia M, Valente M, Furian L, Toscano A, Mazzucco G, Barreca A, Bussolino S, Gesualdo L, Stratta P, Rigotti P, Citterio F, Biancone L, Schena FP. Potential role of effector memory T cells in chronic T cell-mediated kidney graft rejection. Nephrol Dial Transplant. 2016; 31:2131-2142. PubMed PMID: 27369853. (I.F. 4.085)

Cox SN, Pesce F, El-Sayed Moustafa JS, Sallustio F, Serino G, Kkoufou C, Giampetruzzi A, Ancona N, Falchi M, Schena FP; European IgAN Consortium.. Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network. J Intern Med. 2016 Oct 11. doi: 10.1111/joim.12565. [Epub ahead of print] PubMed PMID: 27730700. (I.F. 7.803)

Parodi F, Carosio R, Ragusa M, Di Pietro C, Maugeri M, Barbagallo D, Sallustio F, Allemanni G, Pistillo MP, Casciano I, Forlani A, Schena FP, Purrello M, Romani M, Banelli B. Epigenetic dysregulation in neuroblastoma: A tale of miRNAs and DNA methylation. Biochim Biophys Acta. 2016;1859:1502-1514. doi: 10.1016/j.bbagrm.2016.10.006. PubMed PMID: 27751904. (I.F. 5.083)

De Palma G, Sallustio F, Curci C, Galleggiante V, Rutigliano M, Serino G, Ditonno P, Battaglia M, Schena FP. The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma. J Cancer. 2016 Sep 27;7(14):1960-1967. PubMed PMID: 27877211. (I.F. 3.609)

Bellur SS, Lepeytre F, Vorobyeva O, Troyanov S, Cook HT, Roberts IS; International IgA Nephropathy Working Group.. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney Int. 2017 Jan;91(1):235-243. doi: 10.1016/j.kint.2016.09.029. PubMed PMID: 27914703. (I.F. 7.683)

Binetti G, Del Coco L, Ragone R, Zelasco S, Perri E, Montemurro C, Valentini R, Naso D, Fanizzi FP, Schena FP. Cultivar classification of Apulian olive oils: Use of artificial neural networks for comparing NMR, NIR and merceological data. Food Chem. 2017 Mar 15;219:131-138. doi: 10.1016/j.foodchem.2016.09.041. PubMed PMID: 27765209.(I.F. 4.052)

Sallustio F, Curci C, Aloisi A, Toma CC, Marulli E, Serino G, Cox SN, De Palma G, Stasi A, Divella C, Rinaldi R, Schena FP. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration. Sci Rep. 2017 Aug 15;7(1):8225. doi: 10.1038/s41598-017-08474-0. PubMed PMID: 28811645; PubMed Central PMCID: PMC5557965. L (I.F. 4.122)

Schena FP, Nistor I, Curci C. Transcriptomics in kidney biopsy is an untapped resource for precision therapy in nephrology: a systematic review. Nephrol Dial Transplant. 2017 Aug 1. doi: 10.1093/ndt/gfx211. [Epub ahead of print] PubMed PMID: 28992289. (I.F. 4.6)

Schena FP, Serino G, Sallustio F, Falchi M, Cox SN. Omics studies for comprehensive understanding of immunoglobulin A nephropathy: state-of-the-art and future directions. Nephrol Dial Transplant. 2018 Jun 13. doi: 10.1093/ndt/gfy130. PMID: 29905852 (I.F. 4.6)

Natale P, Palmer SC, Ruospo M, Saglimbene VM, Craig JC, Vecchio M, Samuels JA, Molony DA, Schena FP, Strippoli GF. Immunosuppressive agents for treating IgA nephropathy. Cochrane Database Syst Rev. 2020 Mar 12;3(3):CD003965. doi: 10.1002/14651858.CD003965.pub3. PMID: 32162319; PMCID: PMC7066485.

Schena FP, Cox SN. IgAN Genetic Risk Score in the Clinical Setting. Kidney Int Rep. 2020; 5:1627-1629. doi: 10.1016/j.ekir.2020.07.032. PMID: 33104093; PMCID: PMC7572307.

Cox SN, Chiurlia S, Divella C, Rossini M, Serino G, Bonomini M, Sirolli V, Aiello FB, Zaza G, Squarzoni I, Gangemi C, Stangou M, Papagianni A, Haas M, Schena FP. Formalin-fixed paraffin-embedded renal biopsy tissues: an underexploited biospecimen resource for gene expression profiling in IgA nephropathy. Sci Rep. 2020 Sep 16;10(1):15164. doi: 10.1038/s41598-020-72026-2. PMID: 32938960; PMCID: PMC7494931.


Inker LA, Heerspink HJL, Tighiouart H, Chaudhari J, Miao S, Diva U, Mercer A, Appel GB, Donadio JV, Floege J, Li PKT, Maes BD, Locatelli F, Praga M, Schena FP, Levey AS, Greene T. Association of Treatment Effects on Early Change in Urine Protein and Treatment Effects on GFR Slope in IgA Nephropathy: An Individual Participant Meta-analysis. Am J Kidney Dis. 2021 Mar 26:S0272-6386(21)00502-3. doi: 10.1053/j.ajkd.2021.03.007. Epub ahead of print. PMID: 33775708.


Kouri NM, Stangou M, Lioulios G, Mitsoglou Z, Serino G, Chiurlia S, Cox SN, Stropou P, Schena FP, Papagianni A. Serum Levels of miR-148b and Let-7b at Diagnosis May Have Important Impact in the Response to Treatment and Long-Term Outcome in IgA Nephropathy. J Clin Med. 2021 May 5;10(9):1987. doi: 10.3390/jcm10091987. PMID: 34063140; PMCID: PMC8125269.


Del Coco L, Girelli CR, Angilè F, Mascio I, Montemurro C, Distaso E, Tamburrano P, Chiurlia S, Clodoveo ML, Corbo F, Amirante R, Schena FP, Fanizzi FP. NMR-based metabolomic study of Apulian Coratina extra virgin olive oil extracted with a combined ultrasound and thermal conditioning process in an industrial setting. Food Chem. 2021 May 30; 345:128778. doi: 10.1016/j.foodchem.2020.128778. Epub 2020 Dec 3.PMID: 33310250


Schena FP, Anelli VW, Trotta J, Di Noia T, Manno C, Tripepi G, D'Arrigo G, Chesnaye NC, Russo ML, Stangou M, Papagianni A, Zoccali C, Tesar V, Coppo R; members of the VALIGA study. Development and testing of an artificial intelligence tool for predicting end-stage kidney disease in patients with immunoglobulin A nephropathy. Kidney Int. 2021 May;99(5):1179-1188. doi: 10.1016/j.kint.2020.07.046. Epub 2020 Sep 2.PMID: 32889014 


Aresta AM, De Vietro N, Clodoveo ML, Amirante R, Corbo F, Schena FP, Zambonin C. Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology. J Pharm Biomed Anal. 2021 Sep 5;203:114204. doi: 10.1016/j.jpba.2021.114204. Epub 2021 Jun 10. PMID: 34130008.


Schena G, Carmosino M, Chiurlia S, Onuchic L, Mastropasqua M, Maiorano E, Schena FP, Caplan MJ. Physiol Rep. β3 adrenergic receptor as potential therapeutic target in ADPKD. 9: e15058, 2021.


Alongi M, Lucci P, Clodoveo ML, Schena FP, Calligaris S. Oleogelation of extra virgin olive oil by different oleogelators affects the physical properties and the stability of bioactive compounds. Food Chem. 368:130779, 2022.


Neuen BL, Tighiouart H, Heerspink HJL, Vonesh EF, Chaudhari J, Miao S, Chan TM, Fervenza FC, Floege J, Goicoechea M, Herrington WJ, Imai E, Jafar TH, Lewis JB, Li PKT, Locatelli F, Maes BD, Perrone RD, Praga M, Perna A, Schena FP, Wanner C, Wetzels JFM, Woodward M, Xie D, Greene T, Inker LA. CKD-EPI Clinical Trials. Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression. J Am Soc Nephrol. 33: 291-303, 2022.


Kouri MN, Stangou M, Lioulios G, Mitsoglou Z, Serino G, Chiurlia S, Cox SN, Stropou P, Schena FP, Papagianni A. Serum Levels of miR-148b and Let-7b at Diagnosis May Have Important Impact in the Response to Treatment and Long-Term Outcome in IgA Nephropathy. J Clin Med. 10: 1987, 2022.


Schena FP, Tripepi G, Rossini M, Abbrescia DI, Manno C. Erratum: Randomized clinical study to evaluate the effect of personalized therapy on patients with immunoglobulin A nephropathy. Clin Kidney J. 15: 895-902, 2022.


Schena FP, Anelli VW, Di Noia T, Tripepi G, Abbrescia Di, Stangou M, Papagianni A, Russo ML, D’arrigo G, Manno C. Post-hoc analysis of a toll to predict kidnbey failure in patients with IgA nephropathy. J Nephrol. 35:1953-1971,2022.


Schena FP, Anelli VW, Abbrescia DI, Di Noia T. Prediction of chronic disease and its progression by artificial intelligence algorithms. J Nephrol. 35: 1953-1971, 2022.


Ohyama Y, Yamaguchi H, Ogata S, Chiurlia S, Cox SN, Kouri NM, Stangou MJ, Nakajima K, Hayashi H, Inaguma D, Hasegawa M, Yuzawa Y, Tsuboi N, Renfrow MB, Novak J, Papagianni AA, Schena FP, Takahashi K. Racial heterogeneity of IgA1 hing-region O-glycoforms in patients with IgA nephropathy. iScience 25: 1- 16, 2022.


Sever MS, Biesen WV, Vanholder R, Mallick N, London G, Schena FP, Nagy J, Butorovik-Ponikvar J, Heering P, Maggiore U, Mariat C, Watschinger B, Oniscu G, Peruzzi L, Gandolfini I, Hellemans R, Abramowicz D, Pascual J, Hibrands L. Ethical and medical dilemmas in paid living kidney donor transplantation. Transplantation Review 36: 1-7, 2022.


Lunardi F, Abbrescia DI, L. Vedovelli L, Pezzuto P, Fortarezza F, Comacchio Gm, Guzzardo V, Ferrigno P, Ioy M, Giraudo C, Fraia As, Faccioli E, Braccioni F, Cozzi E, Gregori D, Verleden Gm, Calabrese F, Schena Fp, Rea F. Molecular Profiling of tissue samples with chronic rejection from patients with chronic lung allograft dysfunction: a pilot study in cystic fibrosis patients. Biomolecules 97: 1-14, 2023.


Collier W, Inker La, Haaland B, Appel GB, Badve SV, Caravaca-Fontàan F, Chalmers C, Floege J, Goicoechea M, Imai E, Jafar TH, Lewis JB, Li PKT, Locatelli F, Maes BD, Neuen BL, Perrone RD, Remuzzi G, Schena FP, Wanner C, Heerspink HJL, Greene T. Evaluaton of variation in the performance of GFR slope as a surrogate end point for kidney failure in clinical trials that differ by severity of CKD. Clin American Journ of Nephrol. 18: 183-192, 2023.


Heerspink HJL, Inker LA, Tighiouart H, Collier WH, Haaland B, Luo J, Appel GB, Chan TM, Estacio RO, Fervenza F, Floege J, Imai E, Jafar TH, Lewis JB, Li PKT, Locatelli F, Maes BD, Perna A, Perrone RD, Praga M, Schena FP, Wanner C, Xie D, Greene T. Change in Albuminuria and GFR slope as joint surrogate end points for kidney failure: implications for phase 2 clinical trials in CKD. JASN. 34: 955-968, 2023


Inker LA, Collier W, Greene T, MIAO S, Chaudhari J, Appel GB, Badve SV, Caravaca-Fontan F, Delvecchio L, Floege J, Goicoechea M, Haaland B, Harrington WG, Imai E, Jafar TH, Lewis JB, Li PKT, Maes BD, Neuen BL, Perrone RD, Remuzzi G, Schena FP, Wanner C, Wetzels JFM, Woodward M, Heerspink HJL. A meta-analysis of GFR slope as a surrogate endpoint for kidney failure. Nature Medicine. 29: 1867-1876, 2023. 


Aiello FB, Ranelletti FO, Liberatore M, Felaco P, De Luca G, Lamolinara A, Schena FP, Bonomini M. Independent prognostic and predicitive role of interstitial macrophages in kidney biopsies of IgA nephropathy patients. Journal of Personalized Medicine. 13:935, 2023.




Schena FP, Serino G, Sallustio F. MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring. Nephrol Dial Transplant. 29: 755-63, 2014. (I.F. 3.488).

Schena FP. Biomarkers and personalized therapy in chronic kidney diseases. Expert Opin Investig Drugs. 23:1051-4, 2014(I.F. 3.284).

Schena FP., Sallustio F. and Serino G. microRNAs in glomerular diseases from pathophysiology to potential treatment target. Clinical Science 128: 775–788, 2015 (Printed in Great Britain). (I.F.5.598).

Sallustio F., Serino G., and Schena FP. Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury. BioResearch Open Access, 4: 326-33, 2015 (I.F.  N/A)

Serino G, Curci C, Schena FP. Role of miR-422a and kallikrein-related peptidase 4 implicated in the development of lupus nephritis. Do we work in this direction? Nephrol Dial Transplant. 2015 Nov 27. pii: gfv396  (I.F.3.577).

D1 Palma G, Sallustio F, Schena FP. Clinical Application of Human Urinary Extracellular Vesicles in Kidney and Urologic Diseases. Int J Mol Sci. 17: E1043, 2016 (I.F. 3.257)

Nerini E, Bruno F, Citterio F, Schena FP. Nonadherence to immunosuppressive therapy in kidney transplant recipients: can technology help? J Nephrol. 2016; 29:627-36. doi: 10.1007/s40620-016-0273-x. Review. PubMed PMID: 26885659. (I.F. 1.352)

Schena FP, Manno C. Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2016; 374:992. doi: 10.1056/NEJMc1600141#SA3. PubMed PMID: 26962739. (I.F. 59.558)

Lai KN, Tang SC, Schena FP, Novak J, Tomino Y, Fogo AB, Glassock RJ. IgA nephropathy. Nat Rev Dis Primers. 2016 Feb 11;2:16001. doi: 10.1038/nrdp.2016.1. PubMed PMID: 27189177. (I.F. 16.071)

Sciancalepore AG, Portone A, Moffa M, Persano L, De Luca M, Paiano A, Sallustio F, Schena FP, Bucci C, Pisignano D. Micropatterning control of tubular commitment in human adult renal stem cells. Biomaterials. 2016; 94:57-69. doi: 10.1016/j.biomaterials.2016.03.042. PubMed PMID: 27105437. (I.F. 5.083)

Schena FP, Nistor I. Epidemiology of IgA Nephropathy: A Global Perspective. Semin Nephrol. 2018 Sep;38(5):435-442. doi: 10.1016/j.semnephrol.2018.05.013. PMID: 30177024 (I.F. 3.97)


Schena FP, Cox SN. Biomarkers and Precision Medicine in IgA Nephropathy. Semin Nephrol. 2018 Sep;38(5):521-530. doi: 10.1016/j.semnephrol.2018.05.022. PMID: 30177024 (I.F. 3.97)



Schena FP, Esposito P, Rossini M. A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease. Int J Mol Sci. 2020 Jan 14;21: 525. doi: 10.3390/ijms21020525. PMID: 31947692


Vistoli F, Furian L, Maggiore U, Caldara R, Cantaluppi V, Ferraresso M, Zaza G, Cardillo M, Biancofiore G, Menichetti F, Russo A, Turillazzi E, Di Paolo M, Grandaliano G, Boggi U; Italian National Kidney Transplantation Network; The Joint Committee Of The Italian Society Of Organ Transplantation And The Italian Society Of Nephrology. COVID-19 and kidney transplantation: an Italian survey and consensus. J Nephrol. 33: 667-680, 2020


Schena FP, Cox SN. IgAN genetic risk score in the clinical setting. Kidney Int Rep. 5: 1627-1629, 2020


Schena FP, Rossini M, Abbrescia DI, Zaza G. The molecular mechanism of inflammation and scarring in the kidneys of immunoglobulin A nephropathy: Gene involvement in the mechanism of inflammation and scarring in kidney biopsy of IgAN patients. Semin Immunopathol. 43: 691-705, 2021.


Schena FP, Cox SN. New directions in pathogenesis of primary erythrocytosis in IgAN. EBioMedicine. 76: 103834, 2022.


Schena FP, Magistroni R, Narducci F, Abbrescia DI, Anelli VW, Di Noia T. Artificial intelligence in glomerular disease. Pediatr Nephrol. 37: 2533-2545, 2022.