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La Fondazione, a seguito di un accordo di collaborazione con il Consorzio C.A.R.S.O., sito nel Campus, utilizza le infrastrutture e le apparecchiature scientifiche del Consorzio. Svolge attività di ricerca nel campo delle omiche per la Medicina di Precisione e per la Terapia Personalizzata nel campo delle malattie renali

L’attività di ricerca è documentata dalle seguenti pubblicazioni:

Lavori originali

Sallustio F, Costantino V, Cox SN, Loverre A, Divella C, Rizzi M, Schena FP. Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvescicle-shuttled decorin. Kidney Int. 83: 392-403, 2013. (I.F. 7.916)

Sallustio F, Serino G, Costantino V, Curci C, Cox SN, De Palma G, Schena FP. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. PLoS One. 8: e68296, 2013. (I.F. 3.730)

Sallustio F, Cox SN, Serino G, Curci C, Pesce F, De Palma G, Papagianni A, Kirmizis D, Falchi M, Schena FP. Genome-wide scan identifies a copy number variable region at 3p21.1 that influences the TLR9 expression levels in IgA nephropathy patients. Eur J Hum Genet. 23: 940-8, 2014. (I.F. 4.225)

Serino G, Sallustio F, Curci C, Cox SN, Pesce F, De Palma G, Schena FP. Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy. Nephrol Dial Transplant. 30:1132-9, 2015. (I.F. 3.488)

Cox SN, Serino G, Sallustio F, Blasi A, Rossini M, Pesce F, Schena FP. Altered monocyte expression and expansion of non-classical monocyte subset in IgA nephropathy patients. Nephrol Dial Transplant. 2015 Mar 13. pii: gfv017. [Epub ahead of print] PubMed PMID: 25770168. (I.F. 3.488)

Pesce F; Diciolla M; Binetti G; Naso D; Ostuni VC; Di Noia T; Vagane AM; Bjorneklett R; Suzuki H; Tomino Y; Di Sciascio E; Schena FP. Clinical decision support system for end-stage kidney disease risk estimation in IgA nephropathy patients. Nephrol Dial Transplant 31: 80-6, 2015 (I.F. 3.488)

Serino G, Pesce F, Sallustio F, De Palma G, Cox SN, Curci C, Zaza G, Lai KN, Leung JC, Tang SC, Papagianni A, Stangou M, Goumenos D, Gerolymos M, Takahashi K, Yuzawa Y, Maruyama S, Imai E, Schena FP. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. Kidney Int. 2015 Nov 18. doi: 10.1038/ki.2015.333. (I.F. 8.563)

Sallustio F, Serino G, Cox SN, Dalla Gassa A, Curci C, De Palma G, Banelli B, Zaza G, Romani M, Schena FP. Aberrantly Methylated DNA Regions Lead to Low Activation of CD4+ T Cells in IgA Nephropathy. Clin Sci (Lond). 2016,130: 735-748 (I.F. 5.598)

Piccinonna S, Ragone R, Stocchero M, Del Coco L, De Pascali SA, Schena FP, Fanizzi FP. Robustness of NMR-based metabolomics to generate comparable data sets for olive oil cultivar classification. An inter-laboratory study on Apulian olive oils. Food Chem. 2016; 199:675-83. doi: 10.1016/j.foodchem.2015.12.064. PubMed PMID: 26776024. (I.F.4.052)

Inker LA, Mondal H, Greene T, Masaschi T, Locatelli F, Schena FP, Katafuchi R, Appel GB, Maes BD, Li PK, Praga M, Del Vecchio L, Andrulli S, Manno C, Gutierrez E, Mercer A, Carroll KJ, Schmid CH, Levey AS. Early Change in Urine Protein as a Surrogate End Point in Studies of IgA Nephropathy: An Individual-Patient Meta-analysis. Am J Kidney Dis. 2016; 68:392-401. doi: 10.1053/j.ajkd.2016.02.042. PubMed PMID: 27032886. (I.F. 6.269)

Curci C, Sallustio F, Serino G, De Palma G, Trpevski M, Fiorentino M, Rossini M, Quaglia M, Valente M, Furian L, Toscano A, Mazzucco G, Barreca A, Bussolino S, Gesualdo L, Stratta P, Rigotti P, Citterio F, Biancone L, Schena FP. Potential role of effector memory T cells in chronic T cell-mediated kidney graft rejection. Nephrol Dial Transplant. 2016; 31:2131-2142. PubMed PMID: 27369853. (I.F. 4.085)

Cox SN, Pesce F, El-Sayed Moustafa JS, Sallustio F, Serino G, Kkoufou C, Giampetruzzi A, Ancona N, Falchi M, Schena FP; European IgAN Consortium.. Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network. J Intern Med. 2016 Oct 11. doi: 10.1111/joim.12565. [Epub ahead of print] PubMed PMID: 27730700. (I.F. 7.803)

Parodi F, Carosio R, Ragusa M, Di Pietro C, Maugeri M, Barbagallo D, Sallustio F, Allemanni G, Pistillo MP, Casciano I, Forlani A, Schena FP, Purrello M, Romani M, Banelli B. Epigenetic dysregulation in neuroblastoma: A tale of miRNAs and DNA methylation. Biochim Biophys Acta. 2016;1859:1502-1514. doi: 10.1016/j.bbagrm.2016.10.006. PubMed PMID: 27751904. (I.F. 5.083)

De Palma G, Sallustio F, Curci C, Galleggiante V, Rutigliano M, Serino G, Ditonno P, Battaglia M, Schena FP. The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma. J Cancer. 2016 Sep 27;7(14):1960-1967. PubMed PMID: 27877211. (I.F. 3.609)

Bellur SS, Lepeytre F, Vorobyeva O, Troyanov S, Cook HT, Roberts IS; International IgA Nephropathy Working Group.. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney Int. 2017 Jan;91(1):235-243. doi: 10.1016/j.kint.2016.09.029. PubMed PMID: 27914703. (I.F. 7.683)

Binetti G, Del Coco L, Ragone R, Zelasco S, Perri E, Montemurro C, Valentini R, Naso D, Fanizzi FP, Schena FP. Cultivar classification of Apulian olive oils: Use of artificial neural networks for comparing NMR, NIR and merceological data. Food Chem. 2017 Mar 15;219:131-138. doi: 10.1016/j.foodchem.2016.09.041. PubMed PMID: 27765209.(I.F. 4.052)

Sallustio F, Curci C, Aloisi A, Toma CC, Marulli E, Serino G, Cox SN, De Palma G, Stasi A, Divella C, Rinaldi R, Schena FP. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration. Sci Rep. 2017 Aug 15;7(1):8225. doi: 10.1038/s41598-017-08474-0. PubMed PMID: 28811645; PubMed Central PMCID: PMC5557965. L

 

Review

Schena FP, Serino G, Sallustio F. MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring. Nephrol Dial Transplant. 29: 755-63, 2014. (I.F. 3.488).

Schena FP. Biomarkers and personalized therapy in chronic kidney diseases. Expert Opin Investig Drugs. 23:1051-4, 2014(I.F. 3.284).

Schena FP., Sallustio F. and Serino G. microRNAs in glomerular diseases from pathophysiology to potential treatment target. Clinical Science 128: 775–788, 2015 (Printed in Great Britain). (I.F.5.598).

Sallustio F., Serino G., and Schena FP. Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury. BioResearch Open Access, 4: 326-33, 2015 (I.F.  N/A)

Serino G, Curci C, Schena FP. Role of miR-422a and kallikrein-related peptidase 4 implicated in the development of lupus nephritis. Do we work in this direction? Nephrol Dial Transplant. 2015 Nov 27. pii: gfv396  (I.F.3.577).

De Palma G, Sallustio F, Schena FP. Clinical Application of Human Urinary Extracellular Vesicles in Kidney and Urologic Diseases. Int J Mol Sci. 17: E1043, 2016 (I.F. 3.257)

Nerini E, Bruno F, Citterio F, Schena FP. Nonadherence to immunosuppressive therapy in kidney transplant recipients: can technology help? J Nephrol. 2016; 29:627-36. doi: 10.1007/s40620-016-0273-x. Review. PubMed PMID: 26885659. (I.F. 1.352)

Schena FP, Manno C. Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2016; 374:992. doi: 10.1056/NEJMc1600141#SA3. PubMed PMID: 26962739. (I.F. 59.558)

Lai KN, Tang SC, Schena FP, Novak J, Tomino Y, Fogo AB, Glassock RJ. IgA nephropathy. Nat Rev Dis Primers. 2016 Feb 11;2:16001. doi: 10.1038/nrdp.2016.1. PubMed PMID: 27189177. 

Sciancalepore AG, Portone A, Moffa M, Persano L, De Luca M, Paiano A, Sallustio F, Schena FP, Bucci C, Pisignano D. Micropatterning control of tubular commitment in human adult renal stem cells. Biomaterials. 2016; 94:57-69. doi: 10.1016/j.biomaterials.2016.03.042. PubMed PMID: 27105437. (I.F. 5.083)

Schena FP, Nistor I, Curci C. Transcriptomics in kidney biopsy is an untapped resource for precision therapy in nephrology: a systematic review. Nephrol Dial Transplant. 2017 Aug 1. doi: 10.1093/ndt/gfx211. [Epub ahead of print] PubMed PMID: 28992289.